Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate
نویسندگان
چکیده
منابع مشابه
Notch signaling regulates follicular helper T cell differentiation.
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study, we show that Notch signaling in T cells is a major player in the development and function of TFH cells. T cell-specific gene ablation of No...
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The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, and immunoregulation. Multiple sclerosis (MS) is an incurable yet treatable autoimmune chronic inf...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2018
ISSN: 1933-0219,1935-3456
DOI: 10.1038/s41385-018-0012-9